|
|
Importance of physical activity in patients with diabetes
Kozáková, Eva ; Škrha, Jan (advisor) ; Pehr, Martin (referee)
Aim of the thesis: The research aimed to evaluate the importance of long-term regular physical activity in patients with diabetes. Methods: In total, 53 patients with diagnosed diabetes from the Third Department of Internal Medicine of the General University Hospital in Prague were selected for the research. In order to achieve the aim of the study, a combination of data collection in the form of an anonymous questionnaire survey of own design and laboratory results from the medical records in the hospital's information system Medea was used. During the completion of the questionnaire, the patients were consulted in detail and they had the opportunity to ask their own questions and receive a short education on the subject. All data were recorded in tables and subsequently processed into graphs in the computer program Microsoft Office Excel. Statistical evaluation was performed using Tibco Statistica 14.0 software. Results: Regular physical activity is associated with more favourable laboratory results. The most important parameter in assessing physical activity was a question about daily physical activity lasting at least 30 minutes. Patients who were physically active more than 30 minutes per day had significantly better HbA1c (50±9 vs. 60±15 mmol/mol, p<0.01), total cholesterol (3.7±0.8 vs....
|
|
|
Host-microbe interactions and its consequences for intestinal inflammation and carcinogenesis
Kejzlarová, Leona ; Kverka, Miloslav (advisor) ; Smrž, Daniel (referee)
A number of physiological and pathological processes, including the transition from chronic inflammation to cancer, are affected by commensal microbes. However, abundance of microbes and ability to produce active metabolites in the intestine depend on environmental factors, particularly diet. Microbes can influence this process in two ways, by producing genotoxic substances that directly damage the epithelium or by stimulating the inflammatory response. The aim of my thesis was to study the interaction among gut microbiota, diet and the immune system with the subsequent influence on the development of colorectal cancer (CRC) in an experimental mouse model. Animals were fed synthetic diets containing either normal amounts of animal protein (17%; KD) or elevated amounts of animal protein (51%; HPD) throughout the experiments. Two weeks after the diets were introduced, intestinal tumors were induced by administering azoxymethane (AOM) and inducing acute inflammation with 2% sodium dextran sulfate one week after AOM injection. At the end of the experiment I evaluated the number of tumors in the colon and the status of the immune response in the intestine, mesenteric lymph nodes and spleen. To study the effect of macrophages, a similar experiment was performed in animals with depleted macrophages using...
|
|
|
Study of User Interface for Identifiaction of Meals
Kratochvílová, Marie ; Kajan, Rudolf (referee) ; Herout, Adam (advisor)
This thesis describes the development of mobile application for Windows Phone . Application is focused on choice of meals and identification of meals . The work contains description the different stages of development , starting with analysis of existing applications , specification of the customer requirements and design prototype inteface and finally to its implementation and testing . The work describes the choice of technology for the implementation . Result of my work is an elegant , fast and intuitive application .
|
|
|
Biofilm formation in probiotic cultures and its application in pharmacy
Ryšávka, Petr ; Obruča, Stanislav (referee) ; Vorlová, Lenka (referee) ; Márová, Ivana (advisor)
The work was comprehensively focused on the development of adhesive forms of probiotics in the form of a biofilm on combined carriers with a prebiotic component. The second part dealed with the influence of food on the multiplication and survival of selected types of probiotic bacteria. Subsequently, the effect of individualized probiotic supplements on changes in the human intestinal microbiome was monitored. Suitable adherent probiotic strains for biofilm formation were selected and tested. Methods have been introduced and different variants of carriers for culturing and binding bacteria have been tested. In vitro experiments verified the stability of biofilm stucture and its resistance to low pH, bile and antibiotics in comparison with the planktonic cell form. The antimicrobial effect of probiotic strains in the form of a biofilm was studied. The cultivation of the multispecies biofilm on the combined carrier was optimized and the stability of the biofilm and the final viability of probiotic bacteria were confirmed. Furthermore, the influence of various foods and beverages on the viability of probiotic bacteria was evaluated with emphasis on the simulation of passage through the gastrointestinal tract. Both models, solutions with standardised concentrations of alcohol, sugar, salts, proteins or different pH and different types of real foods and beverages were tested. The effect of food and beverages was tested on monocultures of Lactobacillus acidophilus, Bifidobacterium breve and on probiotic capsules containing a mixed culture of probiotic microorganisms. The survival of probiotics in various food matrices in the simulated gastrointestinal tract was quantitatively different. We managed to define foods suitable for supporting the multiplication of probiotic bacteria. A separate part of the work was focused on the targeted modulation of the intestinal microbiome by individualized probiotics that were prepared on the basis of molecular biological analyzes of the intestinal microbiome aimed at detecting the percentage of lactobacilli, bifidobacteria and phylum Firmicutes and Bacteroidetes. Personalized probiotic supplementation confirmed the positive effect of this approach on microbiome changes, especially on the increase of the content of lactobacilli, bifidobacteria and the overall diversity of the microbiome.
|
|
|
Web Application for Dietary Plan Creation
Matějíček, Vojtěch ; Zendulka, Jaroslav (referee) ; Bartík, Vladimír (advisor)
The aim of this bachelor's thesis was creation of a web application which generates daily menus based on measuring body losses. User creates records of his losses at regular intervals. Food in these menus correspond to food or dietary plan that user chooses from three implemented plans. Therefore, getting familiar with principles of creating web applications and studying theory of implemented dietary plans were both part of this thesis. Application provides opportunity to review recipes and creates shopping lists. Recipes, menus and shopping lists can be printed. User registers and logs in the application with his e-mail and password.
|
|
|
Mobile Application to Control the Diet of Patients on Dialysis
Pavlacký, Ondřej ; Kolář, Dušan (referee) ; Goldmann, Tomáš (advisor)
The goal of this thesis is to create an intuitive mobile application for Android operation system which will help dialysis patients by displaying approximate values of monitored substances in their body and replace classic paper records. Thanks to this mobile application patients are going to have better overview of consumed foodstuffs a help them stick to their diet. When inserting the foodstuff patients will select from the database of foodstuffs and the application will calculate values that the food contains. Patients can also expand the database with their own food. Application will also register periods between dialysis and from the length of the period, patients' weight and their diuresis calculate maximal values of monitored substances (water, potassium and phosphorus). Patients will also see values from passed periods, which will we shown in statistics. Data will be persistently saved in local and remote database. Application is developed on Xamarin platform.
|
|
|
Effect of caloric restriction on neuroplasticity
Sonina, Alisa ; Málková, Petra (advisor) ; Kolář, David (referee)
Calorie restriction has been shown to have a wide range of beneficial effects on health and longevity, although its effects on brain function are not as well known. This paper reviews the current state of research on the effects of calorie restriction on neuroplasticity, including studies examining the molecular, structural, and behavioral effects of dietary restriction in animal and human models. Overall, the evidence suggests that caloric restriction promotes neuroplasticity. However, further research is needed to fully understand the mechanisms underlying these effects and to determine the optimal duration and intensity of caloric restriction. Key words: Caloric restriction, neuroplasticity, diet, cognition, neurogenesis, metabolism
|
|
| |
|
|
Awareness of women with endometriosis about influence of nutrition factors on this disease
Vavroušková, Edita ; Starnovská, Tamara (advisor) ; Fiala, Luděk (referee)
Endometriosis is chronical, inflammatory and very painful disease which contains with estrogen. This disease affect about 10 % of female population in childbearing age. Etiology and pathogenesis of this illness is largely unkown. 20-40 % of women who suffer from endometriosis have concurrent problems with sterility and 50 % of women suffer from various forms of sexual dysfunction, the most common of which is pain. It is assumed that, that symptoms of endometriosis might be affected by diet interventions. Objectives of this thesis: 1. Determine awerness of women in fertile age with endometriosis about influence of nutritional factors on this disease. 2. Determine, if women with endometriosis were instructed by their doctor (gynecologist) about influence of nutritional factors on this disease. 3. Determine, if women with endometriosis changed their eating habits. Part of the research were 212 women with diagnosed endometriosis, which were addresed with using of questionnaire in Nemocnice České Budějovice and electronical questionnaires. Women with diagnosed endometriosis, which were part of the observed sample were not even half informed about influence of nutritional factors on this illness. There has not been proven significant statistical dependence between awerness about influence of nutritional...
|
|
|
Factors of cognitive superaging - a systematic review
Thompsonová, Eliška ; Daďová, Klára (advisor) ; Šteffl, Michal (referee)
Title: Lifestyle Factors and Successful Ageing: A Systematic Review on the SuperAger Phenomenon Background: As the world's population continues to age, the importance of studying the elders becomes more relevant. Age is one of the most prominent risk factors for diseases and understanding how to overcome or prevent the onset of any of them should be the goal for us as health promoting professionals. One of the straight-forward preventive measures is lifestyle. Objectives: The aim of this thesis was to assemble lifestyle factors that potentially contribute to the successful ageing of SuperAgers. Methods: A total of 6 databases were systematically reviewed using keywords established to help answer the review question. 654 studies were identified through the primary search and 10 studies were identified by hand search. After removing the duplicates, another 590 studies were excluded and 20 studies were selected for further eligibility. These studies were assessed using the Newcastle Ottawa Scale. Results: The number of studies finally retrieved from the systematic search was 20. Physical activity was identified as the most likely lifestyle factor to be positively associated with SuperAgeing. Social engagement, diet and adherence to cognitive activities were also found to be influential, as opposed to...
|
guest ::
